Formulation

Ingredients for your formula, and where research is heading

For brand product and R&D teams. Compare ingredients by class and see how research activity and market presence are moving, to set the direction for your next formula.

Formula developmentABL develops formulas for brands as well as manufacturing to the brand's own formula

Research trend

Each line is the number of articles mentioning the ingredient per 100,000 PubMed articles over the previous 12 months. A share factors out PubMed’s own growth. Log scale: the steeper the line, the faster the change.

Time rangeAug 2021 → Aug 2026

Each point is the 12 months to that month; the growth & market view compares the 12 months to the end with the 12 months to the start. Drag either end to the month, or use the arrow keys.

Comparing:PostbioticsTremellaUrolithin AShow selected only

Articles per 100,000 PubMed articles (previous 12 months)

Pick a whole class at the top of the side panel, or use “Top 3” and “All” beside each class; up to ten at a time.

EmergingRisingMature and stableCooling

Show the full data table

Ingredient trend table Aug 2021 → Aug 2026

Sort by any column; click a row to add it to the chart (up to ten)


PostbioticsProbiotics and prebioticsA newer term (consensus definition in 2021); part of the growth reflects the change in naming.	1,010	57	5.45×	+54.3%	26	Emerging
TremellaMushrooms	78	4.4	3.12×	+42.1%	1,099	RisingSmall sample
Urolithin ASpecialty compounds	151	8.6	3.09×	+29.9%	8	EmergingSmall sample
ErgothioneineSpecialty compounds	160	9.1	2.93×	+6.2%	17	EmergingSmall sample
NMNSpecialty compounds	219	12	2.60×	+19.7%	60	Emerging
Digestive enzymesEnzymes	432	25	2.50×	+16.7%	552	Emerging
Lion's maneMushrooms	114	6.5	2.33×	+51.3%	487	EmergingSmall sample
L-tryptophanAmino acids, peptides and proteins	869	49	2.23×	+38.5%	3,542	Rising
RhodiolaBotanicals	138	7.8	1.96×	+44.1%	1,117	Rising
Nicotinamide ribosideSpecialty compounds	132	7.5	1.73×	+33.3%	45	Mature and stable
ProbioticsProbiotics and prebiotics	7,985	454	1.72×	+11.2%	3,741	Rising
Perilla seed oilFatty acids	63	3.6	1.63×	−13.9%	194	EmergingSmall sample
L-theanineAmino acids, peptides and proteins	148	8.4	1.63×	−4.5%	2,106	Rising
Hyaluronic acidSpecialty compounds	126	7.2	1.61×	−7.8%	1,230	Rising
Vitamin B12Vitamins	925	53	1.57×	+23.3%	14,384	Rising
L-arginineAmino acids, peptides and proteins	856	49	1.56×	+15.3%	6,399	Rising
GABAAmino acids, peptides and proteins	393	22	1.56×	+20.1%	1,072	Rising
Collagen peptidesAmino acids, peptides and proteins	175	9.9	1.56×	−2.6%	662	Rising
Vitamin B5 (pantothenic acid)Vitamins	90	5.1	1.55×	+46.7%	23,926	RisingSmall sample
AshwagandhaBotanicals	234	13	1.55×	+19.5%	2,200	Rising
Prebiotic fiberProbiotics and prebiotics	2,665	151	1.53×	+6.0%	1,519	Rising
TaurineAmino acids, peptides and proteins	267	15	1.50×	+29.2%	3,901	Rising
BerberineSpecialty compounds	903	51	1.49×	+17.8%	431	Rising
ReishiMushrooms	409	23	1.46×	+6.4%	9,062	Rising
Alpha-lipoic acidSpecialty compounds	458	26	1.43×	+15.0%	4,110	Rising
QuercetinSpecialty compounds	3,106	176	1.41×	+0.1%	2,090	Rising
PhosphatidylserineSpecialty compounds	57	3.2	1.39×	+29.2%	3,767	Mature and stableSmall sample
AstaxanthinSpecialty compounds	505	29	1.38×	+4.3%	1,181	Rising
BromelainEnzymes	148	8.4	1.36×	+2.6%	5,720	Rising
MelatoninSpecialty compounds	433	25	1.36×	+20.5%	1,804	Rising
Algal oil (DHA)Fatty acids	106	6.0	1.35×	+29.6%	277	Rising
IronMinerals	4,296	244	1.33×	+15.5%	13,636	Rising
GlutamineAmino acids, peptides and proteins	480	27	1.30×	+22.5%	5,215	Rising
Vitamin B3 (niacin)Vitamins	224	13	1.28×	+3.5%	12,906	Rising
MagnesiumMinerals	1,078	61	1.27×	+8.4%	39,884	Rising
CordycepsMushrooms	215	12	1.27×	−5.3%	749	Rising
GingerBotanicals	589	33	1.25×	−1.9%	3,655	Rising
CalciumMinerals	3,387	192	1.25×	+17.6%	31,377	Rising
PQQSpecialty compounds	86	4.9	1.24×	+15.8%	191	Mature and stable
Vitamin B6Vitamins	290	16	1.23×	+11.3%	15,443	Rising
Avocado oilFatty acids	18	1.0	1.22×	−16.4%	109	EmergingSmall sample
ChondroitinSpecialty compounds	55	3.1	1.21×	+16.1%	16,197	Mature and stableSmall sample
Folate (vitamin B9)Vitamins	1,388	79	1.21×	+13.0%	12,239	Rising
Green tea extractBotanicals	1,470	83	1.19×	+1.3%	8,157	Rising
Biotin (vitamin B7)Vitamins	134	7.6	1.19×	+35.3%	9,708	Mature and stable
Vitamin B2 (riboflavin)Vitamins	280	16	1.18×	+10.2%	17,575	Mature and stable
GinsengBotanicals	974	55	1.18×	+7.1%	2,284	Mature and stable
TurmericBotanicals	3,001	170	1.18×	+2.4%	4,133	Rising
SeleniumMinerals	1,081	61	1.16×	+3.3%	8,076	Rising
ChromiumMinerals	239	14	1.16×	+20.0%	27,831	Rising
Vitamin CVitamins	1,103	63	1.14×	+0.4%	26,185	Rising
NattokinaseEnzymes	35	2.0	1.14×	−16.6%	344	EmergingSmall sample
ZincMinerals	1,948	111	1.12×	+10.5%	13,711	Rising
Milk thistleBotanicals	426	24	1.10×	−6.4%	1,833	Rising
ResveratrolSpecialty compounds	1,584	90	1.09×	+4.3%	1,946	Mature and stable
LuteinSpecialty compounds	383	22	1.06×	+3.4%	21,641	Mature and stable
Vitamin B1 (thiamin)Vitamins	396	22	1.05×	+16.8%	10,166	Mature and stable
CoQ10Specialty compounds	789	45	1.01×	+3.7%	3,541	Mature and stable
Chia seed (oil)Fatty acids	169	9.6	1.00×	−12.3%	405	Mature and stable
GlucosamineSpecialty compounds	63	3.6	0.97×	−0.8%	13,882	Mature and stable
CreatineAmino acids, peptides and proteins	793	45	0.97×	−7.6%	2,412	Mature and stable
ElderberryBotanicals	61	3.5	0.96×	−29.2%	1,629	RisingSmall sample
ArtichokeBotanicals	103	5.9	0.92×	−2.3%	545	Cooling
Krill oilFatty acids	40	2.3	0.90×	−33.6%	420	RisingSmall sample
MCT oilFatty acids	163	9.3	0.89×	−2.3%	4,954	Mature and stable
Vitamin EVitamins	640	36	0.87×	−6.8%	22,412	Mature and stable
Vitamin D3Vitamins	585	33	0.83×	−9.6%	15,087	Mature and stable
Fish oilFatty acids	1,384	79	0.80×	+0.2%	5,434	Cooling
Flaxseed oilFatty acids	70	4.0	0.77×	+4.9%	1,502	Cooling
Vitamin K2Vitamins	268	15	0.71×	−6.7%	4,426	Cooling
MSM (methylsulfonylmethane)Specialty compounds	14	0.8	0.65×	−23.5%	1,842	CoolingSmall sample

Tags are fixed on 2025 vs 2020 and do not follow the time range: Emerging = change in share ≥ 1.5× and fewer than 1,000 labels on market; Rising ≥ 1.1×; Mature and stable 0.85–1.1×; Cooling < 0.85×. “Small sample” marks ingredients with fewer than 50 articles in either year.

Data and method

Research activity: PubMed records whose title or abstract matches the search terms, counted by the date they were added to PubMed (each record once), divided by all PubMed records added in the same period and expressed per 100,000. Market presence: labels currently marked on-market in the NIH Dietary Supplement Label Database that mention the ingredient. Counts describe activity, not effectiveness.

PubMed, U.S. National Library of Medicine · Dietary Supplement Label Database, NIH Office of Dietary Supplements · Data retrieved 2026-10-05

Search terms used

Milk thistle — "milk thistle"[tiab] OR silymarin[tiab] OR silybin[tiab] OR silibinin[tiab] OR "Silybum marianum"[tiab]
Turmeric — turmeric[tiab] OR curcumin[tiab] OR "Curcuma longa"[tiab]
Ashwagandha — ashwagandha[tiab] OR "Withania somnifera"[tiab]
Ginger — ginger[tiab] OR "Zingiber officinale"[tiab]
Green tea extract — "green tea"[tiab] OR EGCG[tiab] OR epigallocatechin[tiab]
Elderberry — elderberry[tiab] OR "Sambucus nigra"[tiab]
Rhodiola — rhodiola[tiab]
Ginseng — ginseng[tiab] OR "Panax"[tiab]
Artichoke — artichoke[tiab] OR "Cynara scolymus"[tiab] OR "Cynara cardunculus"[tiab]
Lion's mane — "lion's mane"[tiab] OR Hericium[tiab]
Reishi — reishi[tiab] OR Ganoderma[tiab]
Cordyceps — cordyceps[tiab]
Tremella — tremella[tiab]
Vitamin D3 — "vitamin D3"[tiab] OR cholecalciferol[tiab]
Vitamin K2 — "vitamin K2"[tiab] OR menaquinone*[tiab]
Vitamin B1 (thiamin) — (thiamine[tiab] OR thiamin[tiab] OR "vitamin B1"[tiab]) AND (supplement*[tiab] OR dietary[tiab] OR intake[tiab] OR nutrition*[tiab] OR deficiency[tiab])
Vitamin B2 (riboflavin) — (riboflavin[tiab] OR "vitamin B2"[tiab]) AND (supplement*[tiab] OR dietary[tiab] OR intake[tiab] OR nutrition*[tiab] OR deficiency[tiab])
Vitamin B3 (niacin) — (niacin[tiab] OR niacinamide[tiab] OR "nicotinic acid"[tiab] OR "vitamin B3"[tiab]) AND (supplement*[tiab] OR dietary[tiab] OR intake[tiab] OR nutrition*[tiab] OR deficiency[tiab])
Vitamin B5 (pantothenic acid) — ("pantothenic acid"[tiab] OR pantothenate[tiab] OR "vitamin B5"[tiab]) AND (supplement*[tiab] OR dietary[tiab] OR intake[tiab] OR nutrition*[tiab] OR deficiency[tiab])
Vitamin B6 — ("vitamin B6"[tiab] OR pyridoxine[tiab] OR pyridoxal[tiab]) AND (supplement*[tiab] OR dietary[tiab] OR intake[tiab] OR nutrition*[tiab] OR deficiency[tiab])
Biotin (vitamin B7) — (biotin[tiab] OR "vitamin B7"[tiab]) AND (supplement*[tiab] OR dietary[tiab] OR intake[tiab] OR nutrition*[tiab] OR deficiency[tiab])
Folate (vitamin B9) — (folate[tiab] OR "folic acid"[tiab] OR methylfolate[tiab]) AND (supplement*[tiab] OR dietary[tiab] OR intake[tiab] OR nutrition*[tiab] OR deficiency[tiab])
Vitamin B12 — ("vitamin B12"[tiab] OR cobalamin[tiab] OR methylcobalamin[tiab] OR cyanocobalamin[tiab]) AND (supplement*[tiab] OR dietary[tiab] OR intake[tiab] OR nutrition*[tiab] OR deficiency[tiab])
Vitamin C — ("vitamin C"[tiab] OR "ascorbic acid"[tiab]) AND (supplement*[tiab] OR dietary[tiab] OR intake[tiab] OR nutrition*[tiab] OR deficiency[tiab])
Vitamin E — ("vitamin E"[tiab] OR tocopherol*[tiab] OR tocotrienol*[tiab]) AND (supplement*[tiab] OR dietary[tiab] OR intake[tiab] OR nutrition*[tiab] OR deficiency[tiab])
Magnesium — magnesium[tiab] AND (supplement*[tiab] OR dietary[tiab] OR intake[tiab] OR nutrition*[tiab] OR deficiency[tiab])
Zinc — zinc[tiab] AND (supplement*[tiab] OR dietary[tiab] OR intake[tiab] OR nutrition*[tiab] OR deficiency[tiab])
Selenium — selenium[tiab] AND (supplement*[tiab] OR dietary[tiab] OR intake[tiab] OR nutrition*[tiab] OR deficiency[tiab])
Calcium — (calcium[tiab]) AND (supplement*[tiab] OR dietary[tiab] OR intake[tiab] OR nutrition*[tiab] OR deficiency[tiab])
Iron — (iron[tiab]) AND (supplement*[tiab] OR dietary[tiab] OR intake[tiab] OR nutrition*[tiab] OR deficiency[tiab])
Chromium — (chromium[tiab]) AND (supplement*[tiab] OR dietary[tiab] OR intake[tiab] OR nutrition*[tiab] OR deficiency[tiab])
Fish oil — "fish oil"[tiab] OR eicosapentaenoic[tiab] OR docosahexaenoic[tiab]
Perilla seed oil — perilla[tiab] AND (oil[tiab] OR seed*[tiab])
Flaxseed oil — ("flaxseed oil"[tiab] OR "flax seed oil"[tiab] OR "flax oil"[tiab] OR "linseed oil"[tiab]) AND (supplement*[tiab] OR dietary[tiab] OR intake[tiab] OR nutrition*[tiab] OR deficiency[tiab])
Avocado oil — "avocado oil"[tiab]
Chia seed (oil) — chia[tiab] OR "Salvia hispanica"[tiab]
Krill oil — "krill oil"[tiab]
Algal oil (DHA) — "algal oil"[tiab] OR "algae oil"[tiab] OR "microalgal oil"[tiab] OR Schizochytrium[tiab]
MCT oil — "medium-chain triglyceride*"[tiab] OR "medium chain triglyceride*"[tiab]
Collagen peptides — "collagen peptide*"[tiab] OR "collagen hydrolysate"[tiab] OR "hydrolyzed collagen"[tiab]
L-theanine — theanine[tiab]
GABA — ("gamma-aminobutyric acid"[tiab] OR GABA[tiab]) AND (supplement*[tiab] OR dietary[tiab] OR intake[tiab] OR nutrition*[tiab] OR deficiency[tiab])
Glutamine — glutamine[tiab] AND (supplement*[tiab] OR dietary[tiab] OR intake[tiab] OR nutrition*[tiab] OR deficiency[tiab])
Creatine — creatine[tiab] NOT "creatine kinase"[tiab]
Taurine — (taurine[tiab]) AND (supplement*[tiab] OR dietary[tiab] OR intake[tiab] OR nutrition*[tiab] OR deficiency[tiab])
L-arginine — ("L-arginine"[tiab] OR arginine[tiab]) AND (supplement*[tiab] OR dietary[tiab] OR intake[tiab] OR nutrition*[tiab] OR deficiency[tiab])
L-tryptophan — ("L-tryptophan"[tiab] OR tryptophan[tiab]) AND (supplement*[tiab] OR dietary[tiab] OR intake[tiab] OR nutrition*[tiab] OR deficiency[tiab])
Probiotics — probiotic*[tiab]
Prebiotic fiber — prebiotic*[tiab] OR ((inulin[tiab] OR fructooligosaccharide*[tiab] OR galactooligosaccharide*[tiab] OR polydextrose[tiab] OR "resistant dextrin"[tiab]) AND (supplement*[tiab] OR dietary[tiab] OR intake[tiab] OR nutrition*[tiab] OR deficiency[tiab]))
Postbiotics — postbiotic*[tiab] OR paraprobiotic*[tiab] OR ("heat-killed"[tiab] AND (lactobacill*[tiab] OR bifidobacter*[tiab]))
Nattokinase — nattokinase[tiab]
Digestive enzymes — ("digestive enzyme*"[tiab] OR "enzyme supplement*"[tiab]) AND (supplement*[tiab] OR dietary[tiab] OR intake[tiab] OR nutrition*[tiab] OR deficiency[tiab])
Bromelain — bromelain[tiab]
CoQ10 — "coenzyme Q10"[tiab] OR CoQ10[tiab] OR ubiquinone[tiab] OR ubiquinol[tiab]
Ergothioneine — ergothioneine[tiab]
Glucosamine — glucosamine[tiab] AND (supplement*[tiab] OR dietary[tiab] OR intake[tiab] OR nutrition*[tiab] OR deficiency[tiab])
Hyaluronic acid — ("hyaluronic acid"[tiab] OR hyaluronan[tiab] OR "sodium hyaluronate"[tiab]) AND (supplement*[tiab] OR dietary[tiab] OR "oral administration"[tiab] OR "orally administered"[tiab] OR "oral supplementation"[tiab] OR ingest*[tiab])
Melatonin — melatonin[tiab] AND (supplement*[tiab] OR dietary[tiab] OR intake[tiab] OR nutrition*[tiab] OR deficiency[tiab])
PQQ — pyrroloquinoline[tiab] OR PQQ[tiab]
NMN — "nicotinamide mononucleotide"[tiab]
Nicotinamide riboside — "nicotinamide riboside"[tiab]
Astaxanthin — astaxanthin[tiab]
Lutein — lutein[tiab]
Urolithin A — "urolithin A"[tiab]
Berberine — berberine[tiab]
Quercetin — quercetin[tiab]
Resveratrol — resveratrol[tiab]
Alpha-lipoic acid — "alpha-lipoic acid"[tiab] OR "lipoic acid"[tiab]
Chondroitin — (chondroitin[tiab]) AND (supplement*[tiab] OR dietary[tiab] OR intake[tiab] OR nutrition*[tiab] OR deficiency[tiab])
MSM (methylsulfonylmethane) — methylsulfonylmethane[tiab] OR "methyl sulfonyl methane"[tiab]
Phosphatidylserine — phosphatidylserine[tiab] AND (supplement*[tiab] OR dietary[tiab] OR intake[tiab] OR oral[tiab])

PostbioticsProbiotics and prebioticsA newer term (consensus definition in 2021); part of the growth reflects the change in naming.

5.45×

Emerging

TremellaMushrooms

4.4

3.12×

RisingSmall sample

Urolithin ASpecialty compounds

8.6

3.09×

EmergingSmall sample

ErgothioneineSpecialty compounds

9.1

2.93×

EmergingSmall sample

NMNSpecialty compounds

2.60×

Emerging

Digestive enzymesEnzymes

2.50×

Emerging

Lion's maneMushrooms

6.5

2.33×

EmergingSmall sample

L-tryptophanAmino acids, peptides and proteins

2.23×

Rising

RhodiolaBotanicals

7.8

1.96×

Rising

Nicotinamide ribosideSpecialty compounds

7.5

1.73×

Mature and stable

ProbioticsProbiotics and prebiotics

454

1.72×

Rising

Perilla seed oilFatty acids

3.6

1.63×

EmergingSmall sample

L-theanineAmino acids, peptides and proteins

8.4

1.63×

Rising

Hyaluronic acidSpecialty compounds

7.2

1.61×

Rising

Vitamin B12Vitamins

1.57×

Rising

L-arginineAmino acids, peptides and proteins

1.56×

Rising

GABAAmino acids, peptides and proteins

1.56×

Rising

Collagen peptidesAmino acids, peptides and proteins

9.9

1.56×

Rising

Vitamin B5 (pantothenic acid)Vitamins

5.1

1.55×

RisingSmall sample

AshwagandhaBotanicals

1.55×

Rising

Prebiotic fiberProbiotics and prebiotics

151

1.53×

Rising

TaurineAmino acids, peptides and proteins

1.50×

Rising

BerberineSpecialty compounds

1.49×

Rising

ReishiMushrooms

1.46×

Rising

Alpha-lipoic acidSpecialty compounds

1.43×

Rising

QuercetinSpecialty compounds

176

1.41×

Rising

PhosphatidylserineSpecialty compounds

3.2

1.39×

Mature and stableSmall sample

AstaxanthinSpecialty compounds

1.38×

Rising

BromelainEnzymes

8.4

1.36×

Rising

MelatoninSpecialty compounds

1.36×

Rising

Algal oil (DHA)Fatty acids

6.0

1.35×

Rising

IronMinerals

244

1.33×

Rising

GlutamineAmino acids, peptides and proteins

1.30×

Rising

Vitamin B3 (niacin)Vitamins

1.28×

Rising

MagnesiumMinerals

1.27×

Rising

CordycepsMushrooms

1.27×

Rising

GingerBotanicals

1.25×

Rising

CalciumMinerals

192

1.25×

Rising

PQQSpecialty compounds

4.9

1.24×

Mature and stable

Vitamin B6Vitamins

1.23×

Rising

Avocado oilFatty acids

1.0

1.22×

EmergingSmall sample

ChondroitinSpecialty compounds

3.1

1.21×

Mature and stableSmall sample

Folate (vitamin B9)Vitamins

1.21×

Rising

Green tea extractBotanicals

1.19×

Rising

Biotin (vitamin B7)Vitamins

7.6

1.19×

Mature and stable

Vitamin B2 (riboflavin)Vitamins

1.18×

Mature and stable

GinsengBotanicals

1.18×

Mature and stable

TurmericBotanicals

170

1.18×

Rising

SeleniumMinerals

1.16×

Rising

ChromiumMinerals

1.16×

Rising

Vitamin CVitamins

1.14×

Rising

NattokinaseEnzymes

2.0

1.14×

EmergingSmall sample

ZincMinerals

111

1.12×

Rising

Milk thistleBotanicals

1.10×

Rising

ResveratrolSpecialty compounds

1.09×

Mature and stable

LuteinSpecialty compounds

1.06×

Mature and stable

Vitamin B1 (thiamin)Vitamins

1.05×

Mature and stable

CoQ10Specialty compounds

1.01×

Mature and stable

Chia seed (oil)Fatty acids

9.6

1.00×

Mature and stable

GlucosamineSpecialty compounds

3.6

0.97×

Mature and stable

CreatineAmino acids, peptides and proteins

0.97×

Mature and stable

ElderberryBotanicals

3.5

0.96×

RisingSmall sample

ArtichokeBotanicals

5.9

0.92×

Cooling

Krill oilFatty acids

2.3

0.90×

RisingSmall sample

MCT oilFatty acids

9.3

0.89×

Mature and stable

Vitamin EVitamins

0.87×

Mature and stable

Vitamin D3Vitamins

0.83×

Mature and stable

Fish oilFatty acids

0.80×

Cooling

Flaxseed oilFatty acids

4.0

0.77×

Cooling

Vitamin K2Vitamins

0.71×

Cooling

MSM (methylsulfonylmethane)Specialty compounds

0.8

0.65×

CoolingSmall sample